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Journal Article Review Epublish 12 citations

PubMed: 38276265 DOI: 10.3390/life14010017

Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation.

Life (Basel) 14(1)

Authors: Pedro M Aponte, Miguel A Gutierrez-Reinoso, Manuel Garcia-Herreros

Affiliations

  • Colegio de Ciencias Biológicas y Ambientales (COCIBA), Universidad San Francisco de Quito (USFQ), Quito 170901, Ecuador.
  • Instituto de Investigaciones en Biomedicina "One-Health", Universidad San Francisco de Quito (USFQ), Campus Cumbayá, Quito 170901, Ecuador.
  • Facultad de Ciencias Agropecuarias y Recursos Naturales, Carrera de Medicina Veterinaria, Universidad Técnica de Cotopaxi (UTC), Latacunga 050150, Ecuador.
  • Laboratorio de Biotecnología Animal, Departamento de Ciencia Animal, Facultad de Ciencias Veterinarias, Universidad de Concepción (UdeC), Chillán 3780000, Chile.
  • Instituto Nacional de Investigação Agrária e Veterinária (INIAV), 2005-048 Santarém, Portugal.

Abstract

This review aims to explore advanced reproductive technologies for male fertility preservation, underscoring the essential role that animal models have played in shaping these techniques through historical contexts and into modern applications. Rising infertility concerns have become more prevalent in human populations recently. The surge in male fertility issues has prompted advanced reproductive technologies, with animal models playing a pivotal role in their evolution. Historically, animal models have aided our understanding in the field, from early reproductive basic research to developing techniques like artificial insemination, multiple ovulation, and in vitro fertilization. The contemporary landscape of male fertility preservation encompasses techniques such as sperm cryopreservation, testicular sperm extraction, and intracytoplasmic sperm injection, among others. The relevance of animal models will undoubtedly bridge the gap between traditional methods and revolutionary next-generation reproductive techniques, fortifying our collective efforts in enhancing male fertility preservation strategies. While we possess extensive knowledge about spermatogenesis and its regulation, largely thanks to insights from animal models that paved the way for human infertility treatments, a pressing need remains to further understand specific infertility issues unique to humans. The primary aim of this review is to provide a comprehensive analysis of how animal models have influenced the development and refinement of advanced reproductive technologies for male fertility preservation, and to assess their future potential in bridging the gap between current practices and cutting-edge fertility techniques, particularly in addressing unique human male factor infertility.

MeSH

Fertility, Fertility Preservation, Infertility, Cryopreservation, Infertility, Male, Spermatogenesis, Spermatozoa, Transplantation

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