Journal Article Ppublish 1 citation
PubMed: 38297919 DOI: 10.1002/nbm.5111
Contrast-free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges.
NMR Biomed 37(5):e5111
Authors: Chau Vu, Jian Shen, Clio Gonzalez-Zacarias, Botian Xu, Koen Baas, Soyoung Choi, Aart Nederveen, John C Wood
Affiliations
- Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
- Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
- Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
- Division of Cardiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Abstract
Deoxygenation-based dynamic susceptibility contrast (dDSC) MRI uses respiratory challenges as a source of endogenous contrast as an alternative to gadolinium injection. These gas challenges induce T2*-weighted MRI signal losses, after which tracer kinetics modeling was applied to calculate cerebral perfusion. This work compares three gas challenges, desaturation (transient hypoxia), resaturation (transient normoxia), and SineO (sinusoidal modulation of end-tidal oxygen pressures) in a cohort of 10 healthy volunteers (age 37 ± 11 years; 60% female). Perfusion estimates consisted of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). Calculations were computed using a traditional tracer kinetics model in the time domain for desaturation and resaturation and in the frequency domain for SineO. High correlations and limits of agreement were observed among the three deoxygenation-based paradigms for CBV, although MTT and CBF estimates varied with the hypoxic stimulus. Cross-modality correlation with gadolinium DSC was lower, particularly for MTT, but on a par with agreement between the other perfusion references. Overall, this work demonstrated the feasibility and reliability of oxygen respiratory challenges to measure brain perfusion. Additional work is needed to assess the utility of dDSC in the diagnostic evaluation of various pathologies such as ischemic strokes, brain tumors, and neurodegenerative diseases.
MeSH
Blood, Brain, Work, Hypoxia