Journal Article Epublish
PubMed: 38312351 DOI: 10.17912/micropub.biology.000790
SARS-Cov-2 small viral RNA suppresses gene expression via complementary binding to mRNA 3' UTR.
MicroPubl Biol 2024
Authors: Haley A Delcher, Jeffrey D DeMeis, Nicole Ghobar, Noel L Godang, Sierra L Knight, Shahem Y Alqudah, Kevin N Nguyen, Brianna C Watters, Glen M Borchert
Affiliations
- Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
- Department of Biology, College of Arts and Sciences, University of South Alabama, Mobile, AL.
Abstract
SARS-CoV-2 (SC2) has been intensely studied since its emergence. However, the mechanisms of host immune dysregulation triggered by SC2 remain poorly understood. That said, it is well established that many prominent viral families encode microRNAs (miRNAs) or related small viral RNAs (svRNAs) capable of regulating human genes involved in immune function. Importantly, recent reports have shown that SC2 encodes its own svRNAs. In this study, we have identified 12 svRNAs expressed during SC2 infection and show that one of these svRNAs can regulate target gene expression via complementary binding to mRNA 3' untranslated regions (3'UTRs) much like human microRNAs.
MeSH
Infections, Genes, Rna, Viral, Gene Expression, Sars Virus, 3' Untranslated Regions, Micrornas, Rna, Messenger, Sars-Cov-2