Journal Article Review Epublish 15 citations
PubMed: 38338482 DOI: 10.3390/molecules29030741
Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism.
Molecules 29(3)
Authors: Tongjia Ni, Shuai Zhang, Jia Rao, Jiaqi Zhao, Haiqi Huang, Ying Liu, Yue Ding, Yaqian Liu, Yuchi Ma, Shoujun Zhang, Yang Gao, Liqian Shen, Chuanbo Ding, Yunpeng Sun
Affiliations
- College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
- College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
- Jilin Aodong Health Technology Co. Ltd. Yanbian 133700, China.
- Jilin Aodong Yanbian Pharmaceutical Co. Ltd. Yanbian 133700, China.
- Jilin Jianwei Natural Biotechnology Co. Ltd. Linjiang 134600, China.
- College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China. Jilin Aodong Health Technology Co. Ltd. Yanbian 133700, China.
Abstract
Phlorizin, as a flavonoid from a wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1β/IKB-α/NF-KB signaling pathway. At the same time, it exerts its antibacterial activity by reducing intracellular DNA agglutination, reducing intracellular protein and energy synthesis, and destroying intracellular metabolism. In addition, phlorizin also has various pharmacological effects such as antiviral, antidiabetic, antitumor, and hepatoprotective effects. Based on domestic and foreign research reports, this article reviews the plant sources, extraction, and biological activities of phlorizin, providing a reference for improving the clinical application of phlorizin.
MeSH
Antioxidants, Glucosides, Research, Nf-Kappa B, Phlorhizin
Cited by
- Exploring Postharvest Metabolic Shifts and NOX2 Inhibitory Potential in Strawberry Fruits and Leaves via Untargeted LC-MS/MS and Chemometric Analysis. Metabolites, 2025
- The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome. Nutrients, 2024
- Phloridzin as a Nutraceutical for Cancer Prevention and Therapy: A Comprehensive Review of Its Mechanisms, Bioavailability Challenges and Future Applications. Food Sci Nutr, 2025
- Apple Pomace as a Potential Source of Oxidative Stress-Protecting Dihydrochalcones. Antioxidants (Basel), 2024
- Impact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling. World J Cardiol, 2025
- Phlorizin Protects Against Oxidative Stress and Inflammation in Age-Related Macular Degeneration Model. Biomolecules, 2025
- CRISPRi knockdown of mycobacterial tkt gene potentiates the anti-mycobacterial activity of phyto-compounds from selected medicinal plants. BMC Complement Med Ther, 2025