Journal Article Research Support, Non-U.S. Gov't Ppublish 1 citation
PubMed: 38361451 DOI: 10.1017/S0007114524000473
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris.
Br J Nutr 131(10):1678-1690
Authors: Marianne Bråtveit, Anthea Van Parys, Thomas Olsen, Elin Strand, Ingvild Marienborg, Johnny Laupsa-Borge, Teresa Risan Haugsgjerd, Adrian McCann, Indu Dhar, Per Magne Ueland, Jutta Dierkes, Simon Nitter Dankel, Ottar Kjell Nygård, Vegard Lysne
Affiliations
- Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
- Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.
- Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
- Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.
- Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- Bevital AS, Bergen, Norway.
- Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
- Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway.
- Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Abstract
Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations of these markers. We cross-sectionally analysed 1928 patients with suspected stable angina pectoris (geometric mean age 61), representing elevated CVD risk, to assess associations between dietary macronutrient composition (FFQ) and plasma one-carbon metabolites and related B-vitamin status markers (GC-MS/MS, LC-MS/MS or microbiological assay). Diet-metabolite associations were modelled on the continuous scale, adjusted for age, sex, BMI, smoking, alcohol and total energy intake. Average (geometric mean (95 % prediction interval)) intake was forty-nine (38, 63) energy percent (E%) from carbohydrate, thirty-one (22, 45) E% from fat and seventeen (12, 22) E% from protein. The strongest associations were seen for higher protein intake, i.e. with higher plasma pyridoxal 5'-phosphate (PLP) (% change (95 % CI) 3·1 (2·1, 4·1)), cobalamin (2·9 (2·1, 3·7)), riboflavin (2·4 (1·1, 3·7)) and folate (2·1 (1·2, 3·1)) and lower total homocysteine (tHcy) (-1·4 (-1·9, -0·9)) and methylmalonic acid (MMA) (-1·4 (-2·0, -0·8)). Substitution analyses replacing MUFA or PUFA with SFA demonstrated higher plasma concentrations of riboflavin (5·0 (0·9, 9·3) and 3·3 (1·1, 5·6)), tHcy (2·3 (0·7, 3·8) and 1·3 (0·5, 2·2)) and MMA (2·0 (0·2, 3·9) and 1·7 (0·7, 2·7)) and lower PLP (-2·5 (-5·3, 0·3) and -2·7 (-4·2, -1·2)). In conclusion, a higher protein intake and replacing saturated with MUFA and PUFA were associated with a more favourable metabolic phenotype regarding metabolites associated with CVD risk.
MeSH
Vitamins, Diet, Angina Pectoris, Angina, Stable, Nutritional Physiological Phenomena, Riboflavin, Plasma