System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish 1 citation

PubMed: 38386593 DOI: 10.4049/immunohorizons.2400010

Investigating the Antibody Imprinting Hypothesis among Canadian Paramedics after SARS-CoV-2 Omicron Variant Circulation.

Immunohorizons 8(2):193-197

Authors: Michael Asamoah-Boaheng, Brian Grunau, Mohammad Ehsanul Karim, Iryna Kayda, Justin Yap, Katherine Bessai, David M Goldfarb

Affiliations

  • Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Centre for Advancing Health Outcomes, University of British Columbia, Vancouver, British Columbia, Canada.
  • British Columbia Resuscitation Research Collaborative, Vancouver, British Columbia, Canada.
  • School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Experimental Medicine Graduate Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Faculty of Science, University of British Columbia, Vancouver, British Columbia, Canada.
  • British Columbia Emergency Health Services, British Columbia, Canada.
  • Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Abstract

Recent research has highlighted the Omicron variant's capacity to evade immune protection conferred by wild-type (WT) mRNA vaccines. Despite this observation, the potential involvement of antigenic sin phenomena remains unclear. Our hypothesis posited that a greater number of prior WT vaccine doses might lead to reduced anti-Omicron neutralization Abs following Omicron infection. To investigate this, we analyzed blood samples from human participants in the COVID-19 Occupational Risk, Seroprevalence, and Immunity among Paramedics (CORSIP) study who had received at least one WT mRNA vaccine before contracting Omicron. The exposure variable was the number of WT mRNA vaccines administered, and the outcome was the angiotensin-converting enzyme 2 (ACE-2) percent inhibition specific to the BA.4/BA.5 Omicron Ag. Contrary to expectations, our findings revealed that more WT-based vaccines were associated with an enhanced Omicron-specific immune response.

MeSH

Immune System Phenomena, Sars-Cov-2, Vaccines, Angiotensin-Converting Enzyme 2, Covid-19, Immunity, Severe Acute Respiratory Syndrome-Related Coronavirus, Paramedics