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Journal Article Epublish 8 citations

PubMed: 38386717 DOI: 10.7189/jogh.14.04041

Temporal relationship between inflammation and metabolic disorders and their impact on cancer risk.

J Glob Health 14:04041

Authors: Chenan Liu, Tong Liu, Qingsong Zhang, Mengmeng Song, Qi Zhang, Jinyu Shi, Li Deng, Yue Chen, Xin Zheng, Shiqi Lin, Ziwen Wang, Hailun Xie, Shuohua Chen, Shouling Wu, Hanping Shi

Affiliations

  • Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China. Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China. Laboratory for Clinical Medicine Capital Medical University, Beijing, China.
  • Department of General Surgery, Kailuan General Hospital, Tangshan, China.
  • Cardiovascular Research Institute, University of California, San Francisco, California, USA.
  • Department of Genetics, Yale University School of Medicine, New Haven, USA.
  • Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China. Laboratory for Clinical Medicine Capital Medical University, Beijing, China.
  • Department of Cardiology, Kailuan General Hospital, Tangshan, China.

Abstract

Background

Inflammation and metabolic disorders are closely associated with cancer. Whether inflammation leads to metabolic disorders or vice versa during cancer initiation remains unclear. In this study, we explored this temporal relationship and the co-exposure effect on cancer risk.

Methods

This prospective study had two phases. Initially, we examined the temporal relationship between inflammation (high-sensitivity C-reactive protein (CRP)) and metabolic disorders (metabolic syndrome severity Z-score (MetS-Z)) using a 3.98-year survey and cross-lagged analysis. Subsequently, we assessed the connection of co-exposure to inflammation and metabolic disorders, and the risks of overall cancer, as well as specific obesity-related, non-obesity-related, digestive system, lung, and other cancers using an 11.04-year survey and Cox proportional hazard models.

Results

The cross-lagged analysis revealed that the path coefficient from baseline CRP to follow-up MetS-Z (β2 = 0.032; 95% confidence interval (CI) = 0.026, 0.046) was more significant than the path coefficient from baseline MetS-Z to follow-up CRP (β1 = 0.009; 95% CI = -0.001, 0.019). During the follow-up, 2304 cases of cancer occurred. Compared with the risk of cancer of patients with low average cumulative CRP and MetS-Z, patients with high value had a significantly increased risk (hazard ratio = 1.54, 95% CI = 1.30, 1.83). The mediation analysis showed that MetS-Z mediated the association between CRP levels and overall cancer (12.67%), digestive system cancer (10.16%), and obesity-related cancer risk (13.87%).

Conclusions

Inflammation had a greater impact on metabolic disorders than vice versa. Co-exposure to inflammation and metabolic disorders significantly increased the risk of cancer, particularly digestive system and obesity-related cancers.

Registration

Chinese Clinical Trial Registry: ChiCTR-TNRC-11001489.

MeSH

Global Health, C-Reactive Protein, Neoplasms, Risk, Obesity, Digestive System

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