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Publications

Journal Article Epublish 2 citations

PubMed: 38392590 DOI: 10.3390/jpm14020159

Lymphocyte-to-Monocyte Ratio Might Serve as a Prognostic Marker in Young Patients with Tongue Squamous Cell Carcinoma.

J Pers Med 14(2)

Authors: Sam Augustine Kandathil, Ina Peter Truta, Lorenz Kadletz-Wanke, Gregor Heiduschka, Stefan Stoiber, Lukas Kenner, Harald Herrmann, Harun Huskic, Faris F Brkic

Affiliations

  • Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.
  • Division of Anatomy, Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.
  • Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.
  • Christian Doppler Laboratory for Applied Metabolomics, 1090 Vienna, Austria.
  • Center for Biomarker Research in Medicine, 8010 Graz, Austria.
  • Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
  • Department of Radiation Oncology, Medical University of Vienna, 1090 Vienna, Austria.

Abstract

BACKGROUND

Young patients with tongue squamous cell carcinoma (TSCC) mostly lack typical prognostic markers and face a dire prognosis. The aim of this study was to analyze the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in TSCC patients, with a special emphasis on patients under 45 years.

METHODS

This retrospective study included all patients primarily treated for TSCC. The prognostic relevance of LMR was investigated in terms of predicting the overallsurvival (OS) and disease-free survival (DFS).

RESULTS

A total of 74 patients were included and the young cohort (<45 years) comprised 27 individuals. The mortality and recurrence rates were 39.2% ( = 29) and 37.8% ( = 28), respectively. OS and DFS were significantly shorter in the low LMR group within the whole cohort. Furthermore, low LMR was associated with worse prognosis, particularly inferior OS (median OS 1.7 vs. 14.6 years, = 0.0156) and worse DFS (median DFS 0.8 years vs. not reached, = 0.0405) in the young patient cohort.

CONCLUSIONS

Our results reveal that pretreatment LMR might become a prognostic tool for young TSCC patients, especially due to its availability. However, further studies on larger cohorts are necessary to validate our results.

MeSH

Cells, Monocytes, Tongue, Lymphocytes, Carcinoma, Squamous Cell, Prognosis