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Journal Article Review Epublish 3 citations

PubMed: 38392851 DOI: 10.3390/pathogens13020113

Mucosal Immunity against SARS-CoV-2 in the Respiratory Tract.

Pathogens 13(2)

Authors: Hae-Eun Noh, Min-Seok Rha

Affiliations

  • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Abstract

The respiratory tract, the first-line defense, is constantly exposed to inhaled allergens, pollutants, and pathogens such as respiratory viruses. Emerging evidence has demonstrated that the coordination of innate and adaptive immune responses in the respiratory tract plays a crucial role in the protection against invading respiratory pathogens. Therefore, a better understanding of mucosal immunity in the airways is critical for the development of novel therapeutics and next-generation vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses. Since the coronavirus disease 2019 pandemic, our knowledge of mucosal immune responses in the airways has expanded. In this review, we describe the latest knowledge regarding the key components of the mucosal immune system in the respiratory tract. In addition, we summarize the host immune responses in the upper and lower airways following SARS-CoV-2 infection and vaccination, and discuss the impact of allergic airway inflammation on mucosal immune responses against SARS-CoV-2.

MeSH

Coronavirus, Sars-Cov-2, Vaccines, Covid-19, Immunity, Mucosal, Viruses, Immunity, Severe Acute Respiratory Syndrome-Related Coronavirus

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