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Publications

Journal Article Review Research Support, Non-U.S. Gov't Epublish 6 citations

PubMed: 38397155 DOI: 10.3390/genes15020165

A Comprehensive View on the Protein Functions of Porcine Epidemic Diarrhea Virus.

Genes (Basel) 15(2)

Authors: Xin Li, Yiwan Wu, Zhibin Yan, Gen Li, Jun Luo, Shile Huang, Xiaofeng Guo

Affiliations

  • College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
  • College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
  • Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
  • Department of Hematology and Oncology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
  • Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.

Abstract

Porcine epidemic diarrhea (PED) virus (PEDV) is one of the main pathogens causing diarrhea in piglets and fattening pigs. The clinical signs of PED are vomiting, acute diarrhea, dehydration, and mortality resulting in significant economic losses and becoming a major challenge in the pig industry. PEDV possesses various crucial structural and functional proteins, which play important roles in viral structure, infection, replication, assembly, and release, as well as in escaping host innate immunity. Over the past few years, there has been progress in the study of PEDV pathogenesis, revealing the crucial role of the interaction between PEDV viral proteins and host cytokines in PEDV infection. At present, the main control measure against PEDV is vaccine immunization of sows, but the protective effect for emerging virus strains is still insufficient, and there is no ideal safe and efficient vaccine. Although scientists have persistently delved their research into the intricate structure and functionalities of the PEDV genome and viral proteins for years, the pathogenic mechanism of PEDV remains incompletely elucidated. Here, we focus on reviewing the research progress of PEDV structural and nonstructural proteins to facilitate the understanding of biological processes such as PEDV infection and pathogenesis.

MeSH

Viral Proteins, Infections, Genomics, Viruses, Research, Immunity, Innate, Porcine Epidemic Diarrhea Virus, Epidemics

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