Journal Article Epublish 1 citation
PubMed: 38398004 DOI: 10.3390/biomedicines12020402
Baseline Blood Levels of Mucin-1 Are Associated with Crucial On-Treatment Adverse Outcomes in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Pirfenidone.
Biomedicines 12(2)
Authors: Tang-Hsiu Huang, Sheng-Huan Wei, Hung-I Kuo, Hsin-Yu Hou, Chin-Wei Kuo, Yau-Lin Tseng, Sheng-Hsiang Lin, Chao-Liang Wu
Affiliations
- Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 35 Siaodong Rd. Tainan 704, Taiwan.
- Division of Chest Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Rd. Tainan 704, Taiwan.
- Chest Hospital, Ministry of Health and Welfare, 864 Zhongshan Rd. Rende Dist. Tainan 717, Taiwan.
- Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Rd. Tainan 704, Taiwan.
- Department of Public Health, College of Medicine, National Cheng Kung University, 138 Sheng Li Rd. Tainan 704, Taiwan.
- Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Rd. Tainan 704, Taiwan.
- Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 Dasyue Road, East District, Tainan 701, Taiwan.
- Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung Hsiao Rd. Chiayi 600, Taiwan.
Abstract
Mucin-1 is a multi-functional glycoprotein expressed by type II alveolocytes and may be detectable in the circulation following pulmonary fibrosis. The prognostic utility of baseline pre-treatment blood levels of mucin-1 in patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotics has not yet been fully established. We retrospectively studied a cohort of patients (from two hospitals) with IPF who were receiving pirfenidone for >12 weeks. Baseline blood mucin-1 levels were measured via sandwich enzyme-linked immunosorbent assays. We investigated the performance of mucin-1 levels in longitudinally predicting the risks of acute exacerbation of IPF (AE-IPF) and severe adverse outcomes (SAO), including lung transplantation and death. Seventy patients were included; 20 developed AE-IPF; and 31 had SAO during the follow-up period. Patients with baseline mucin-1 levels ≥2.5 ng/mL had enhanced risks of AE-IPF (adjusted hazard ratio [aHR], 14.07; 95% confidence interval [CI], 4.26-46.49) and SAO within 2 years (aHR, 7.87; 95% CI, 2.86-21.70) and anytime during the follow-up (aHR, 4.68; 95% CI, 2.11-10.39). The risks increased across subgroups with increasing mucin-1 levels. Patients in the "mucin-1 ≥ 2.5" group also exhibited an accelerated decline in D. This study supports baseline blood mucin-1 levels as a biomarker for IPF that predicts adverse outcomes during pirfenidone treatment.
MeSH
Mucins, Mortality, Risk, Mucin-1, Therapeutics, Blood, Idiopathic Pulmonary Fibrosis