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Journal Article Epublish 5 citations

PubMed: 38398943 DOI: 10.3390/mi15020214

Diseased Erythrocyte Enrichment Based on I-Shaped Pillar DLD Arrays.

Micromachines (Basel) 15(2)

Authors: Yao Lv, Jiangbo Wu, Yongqing He, Jie Liu, Wenyu Zhang, Zihan Yan

Affiliations

  • School of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, China.
  • Chongqing Key Laboratory of Micro-Nano System and Intelligent Sensing, Chongqing Technology and Business University, Chongqing 400067, China.

Abstract

Enrichment of erythrocytes is a necessary step in the diagnosis of blood diseases. Due to the high deformability and viscosity of erythrocytes, they cannot be regarded as stable point-like solids, so the influence of their deformability on fluid dynamics must be considered. Therefore, by using the special effect of an I-shaped pillar (I-pillar) on erythrocytes, erythrocytes with different deformability can be made to produce different provisional distances in the chip, so as to achieve the separation of the two kinds of erythrocytes. In this study, a microfluidic chip was designed to conduct a control test between erythrocytes stored for a long time and fresh erythrocytes. At a specific flow rate, the different deformable erythrocytes in the chip move in different paths. Then, the influence of erythrocyte deformability on its movement trajectory was analyzed by two-dimensional finite element flow simulation. DLD sorting technology provides a new method for the sorting and enrichment of diseased erythrocytes.

MeSH

Erythrocytes, Erythrocyte Deformability

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