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Journal Article Review Epublish 5 citations

PubMed: 38399295 DOI: 10.3390/pharmaceutics16020241

Unveiling the Potential of Cannabinoids in Multiple Sclerosis and the Dawn of Nano-Cannabinoid Medicine.

Pharmaceutics 16(2)

Authors: Roua A Nouh, Ahmed Kamal, Oluwaseyi Oyewole, Walaa A Abbas, Bishoy Abib, Abdelrouf Omar, Somaia T Mansour, Anwar Abdelnaser

Affiliations

  • Biotechnology Graduate Program, School of Sciences and Engineering, The American University in Cairo, P.O. Box 74, New Cairo 11835, Egypt.
  • Biochemistry Department, Faculty of Science, Suez University, P.O. Box 43221, Suez 43533, Egypt.
  • Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, P.O. Box 74, New Cairo 11835, Egypt.
  • Institute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, P.O. Box 74, New Cairo 11835, Egypt.

Abstract

Multiple sclerosis is the predominant autoimmune disorder affecting the central nervous system in adolescents and adults. Specific treatments are categorized as disease-modifying, whereas others are symptomatic treatments to alleviate painful symptoms. Currently, no singular conventional therapy is universally effective for all patients across all stages of the illness. Nevertheless, cannabinoids exhibit significant promise in their capacity for neuroprotection, anti-inflammation, and immunosuppression. This review will examine the traditional treatment for multiple sclerosis, the increasing interest in using cannabis as a treatment method, its role in protecting the nervous system and regulating the immune system, commercially available therapeutic cannabinoids, and the emerging use of cannabis in nanomedicine. In conclusion, cannabinoids exhibit potential as a disease-modifying treatment rather than merely symptomatic relief. However, further research is necessary to unveil their role and establish the safety and advancements in nano-cannabinoid medicine, offering the potential for reduced toxicity and fewer adverse effects, thereby maximizing the benefits of cannabinoids.

MeSH

Nervous System, Dronabinol, Autoimmune Diseases, Cannabinoids, Multiple Sclerosis, Immunosuppression Therapy, Therapeutics, Nanomedicine

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