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Journal Article Epublish 3 citations

PubMed: 38400050 DOI: 10.3390/v16020275

Inflammatory Polymorphisms (IL-6 , IL-10 , TNF-α , and IFITM3 ) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors.

Viruses 16(2)

Authors: César Fernández-de-Las-Peñas, Gema Díaz-Gil, Antonio Gil-Crujera, Stella M Gómez-Sánchez, Silvia Ambite-Quesada, Juan Torres-Macho, Pablo Ryan-Murua, Ana I Franco-Moreno, Oscar J Pellicer-Valero, Lars Arendt-Nielsen, Rocco Giordano

Affiliations

  • Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
  • Center for Neuroplasticity and Pain (CNAP), Sensory Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, DK-9220 Aalborg, Denmark.
  • Research group GAMDES, Department of Basic Health Sciences, Universidad Rey Juan Carlos (URJC), 28933 Madrid, Spain.
  • Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, Spain.
  • Department of Medicine, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Image Processing Laboratory (IPL), Universitat de València, Parc Científic, Paterna, 46100 València, Spain.
  • Department of Gastroenterology & Hepatology, Mech-Sense, Clinical Institute, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
  • Steno Diabetes Center North Denmark, Clinical Institute, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
  • Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, DK-9000 Aalborg, Denmark.

Abstract

The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 , IL-10 , TNF-α , and IFITM3 , were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whether the symptoms persisted at the time of the study. At the time of the study (mean: 15.6, SD: 5.6 months after discharge), 89.4% of patients reported at least one post-COVID symptom (mean number of symptoms: 3.0; SD: 1.7). Fatigue (69.3%), pain (40.9%), and memory loss (27.2%) were the most prevalent post-COVID symptoms in the total sample. Overall, no differences in the post-COVID symptoms depending on the IL-6 , IL-10 , TNF-α , and IFITM3 genotypes were seen. The four SNPs assessed, albeit having been previously associated with inflammation and COVID-19 severity, did not cause a predisposition to the development of post-COVID symptoms in the previously hospitalized COVID-19 survivors.

MeSH

Virology, Interleukin-6, Signs And Symptoms, Covid-19, Genotype, Polymorphism, Single Nucleotide, Interleukin-10, Infections

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