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Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish 8 citations

PubMed: 38442771 DOI: 10.1016/j.jaci.2024.02.014

Skin biomarkers predict the development of food allergy in early life.

J Allergy Clin Immunol 153(5):1456-1463.e4

Authors: Evgeny Berdyshev, Jihyun Kim, Byung Eui Kim, Elena Goleva, Taras Lyubchenko, Irina Bronova, Anna Sofia Bronoff, Olivia Xiao, Sehun Jang, Sanghee Shin, Jeongmin Song, Jiwon Kim, Sukyung Kim, Boram Park, Kyunga Kim, Suk-Joo Choi, Soo-Young Oh, Kangmo Ahn, Donald Y M Leung

Affiliations

  • Department of Medicine, National Jewish Health, Denver, Colo.
  • Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.
  • Department of Pediatrics, National Jewish Health, Denver, Colo.
  • Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Department of Pediatrics, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea.
  • Department of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Korea.
  • Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.
  • Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea; Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea; Department of Data Convergence & Future Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.
  • Department of Pediatrics, National Jewish Health, Denver, Colo.

Abstract

BACKGROUND

Food allergy (FA) often occurs in early childhood with and without atopic dermatitis (AD). FA can be severe and even fatal. For primary prevention, it is important to find early biomarkers to predict the future onset of FA before any clinical manifestations.

OBJECTIVE

Our aim was to find early predictors of future onset of FA in the stratum corneum (SC).

METHODS

Skin tape strips were collected from the forearm of newborns (n = 129) at age 2 months, before any signs of clinical FA or AD. Children were clinically monitored until they reached age 2 years to confirm the presence or absence of FA and AD. Skin tape strips were subjected to lipidomic analyses by liquid chromatography-tandem mass spectrometry and cytokine determination by Meso Scale Discovery U-Plex assay.

RESULTS

Overall, 9 of 129 infants (7.0%) developed FA alone and 9 of 129 infants (7.0%) developed FA concomitantly with AD. In the stratum corneum of children with future FA and concomitant AD and FA, absolute amounts of unsaturated (N24:1)(C18-sphingosine)ceramide and (N26:1)(C18-sphingosine)ceramide and their relative percentages within the molecular group were increased compared with the amounts and percentages in healthy children, with P values ranging from less than .01 to less than .05 according to ANOVA. The children with future AD had normal levels of these molecules. IL-33 level was upregulated in those infants with future FA but not in those with future AD, whereas thymic stromal lymphopoietin was upregulated in those with future AD but not in those with future FA. Logistic regression analysis revealed strong FA predicting power for the combination of dysregulated lipids and cytokines, with an odds ratio reaching 101.4 (95% CI = 5.4-1910.6).

CONCLUSION

Noninvasive skin tape strip analysis at age 2 months can identify infants at risk of FA in the future.

MeSH

Cytokines, Skin, Food Hypersensitivity, Hypersensitivity, Sphingosine, Biomarkers, Food, Ceramides, Child, Infant, Allergy

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