Case Reports Ppublish
PubMed: 38464923 DOI: 10.12998/wjcc.v12.i6.1144
Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome: A case report.
World J Clin Cases 12(6):1144-1149
Authors: Xiang-Xiang Wu, Jian Cui, Shi-Yao Wang, Tian-Tian Zhao, Ya-Fei Yuan, Long Yang, Wei Zuo, Wen-Jian Liao
Affiliations
- Department of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. China-Japan Friendship Jiangxi Hospital, Nanchang 330006, Jiangxi Province, China.
- China-Japan Friendship Jiangxi Hospital, Nanchang 330006, Jiangxi Province, China. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
- Department of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
- Department of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. China-Japan Friendship Jiangxi Hospital, Nanchang 330006, Jiangxi Province, China.
Abstract
BACKGROUND
This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome (AS) following coronavirus disease 2019 (COVID-19) in a 33-year-old man diagnosed with Klinefelter syndrome (KS).
CASE SUMMARY
A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19. Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs, accompanied by signs of partial bronchial inflation. Metagenomic next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen. A biopsy specimen revealed organizing pneumonia with alveolar septal thickening. Additionally, extensive auto-antibody tests showed strong positivity for anti-SSA, anti-SSB, anti-Jo-1, and anti-Ro-52. Following multidisciplinary discussions, the patient received a final diagnosis of AS, leading to rapidly progressing respiratory failure.
CONCLUSION
This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.
MeSH
Lung, Covid-19, Klinefelter Syndrome, Diagnosis, Lung Diseases, Lung Diseases, Interstitial