System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Practice Guideline Systematic Review Ppublish 29 citations

PubMed: 38498792 DOI: 10.1200/JCO.24.00032

Vaccination of Adults With Cancer: ASCO Guideline.

J Clin Oncol 42(14):1699-1721

Authors: Mini Kamboj, Kari Bohlke, Deana M Baptiste, Kieron Dunleavy, Abbey Fueger, Lee Jones, Amar H Kelkar, Lisa Y Law, Kristine B LeFebvre, Per Ljungman, Eric D Miller, Larissa A Meyer, Heather N Moore, Heloisa P Soares, Randy A Taplitz, Edom S Woldetsadik, Elise C Kohn

Affiliations

  • Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY.
  • American Society of Clinical Oncology, Alexandria, VA.
  • American Cancer Society, Atlanta, GA.
  • MedStar Georgetown University Hospital, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
  • The Leukemia and Lymphoma Society, Rye Brook, NY.
  • Fight Colorectal Cancer, Arlington, VA.
  • Harvard Medical School, Dana Farber Cancer Institute, Boston, MA.
  • Kaiser Permanente, Roseville, CA.
  • Oncology Nursing Society, Pittsburgh, PA.
  • Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • The Ohio State University Comprehensive Cancer Center, Columbus, OH.
  • The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Duke University Medical Center, Durham, NC.
  • Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT.
  • City of Hope Comprehensive Cancer Center, Duarte, CA.
  • Addis Ababa University, Addis Ababa, Ethiopia.
  • Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, MD.

Abstract

PURPOSE

To guide the vaccination of adults with solid tumors or hematologic malignancies.

METHODS

A systematic literature review identified systematic reviews, randomized controlled trials (RCTs), and nonrandomized studies on the efficacy and safety of vaccines used by adults with cancer or their household contacts. This review builds on a 2013 guideline by the Infectious Disease Society of America. PubMed and the Cochrane Library were searched from January 1, 2013, to February 16, 2023. ASCO convened an Expert Panel to review the evidence and formulate recommendations.

RESULTS

A total of 102 publications were included in the systematic review: 24 systematic reviews, 14 RCTs, and 64 nonrandomized studies. The largest body of evidence addressed COVID-19 vaccines.

RECOMMENDATIONS

The goal of vaccination is to limit the severity of infection and prevent infection where feasible. Optimizing vaccination status should be considered a key element in the care of patients with cancer. This approach includes the documentation of vaccination status at the time of the first patient visit; timely provision of recommended vaccines; and appropriate revaccination after hematopoietic stem-cell transplantation, chimeric antigen receptor T-cell therapy, or B-cell-depleting therapy. Active interaction and coordination among healthcare providers, including primary care practitioners, pharmacists, and nursing team members, are needed. Vaccination of household contacts will enhance protection for patients with cancer. Some vaccination and revaccination plans for patients with cancer may be affected by the underlying immune status and the anticancer therapy received. As a result, vaccine strategies may differ from the vaccine recommendations for the general healthy adult population vaccine.Additional information is available at www.asco.org/supportive-care-guidelines.

MeSH

Cells, Microscopy, Electron, Scanning Transmission, Vaccines, Neoplasms, Vaccination, Therapeutics, Infections, Receptors, Antigen, T-Cell

Cited by