Journal Article Ppublish
PubMed: 38504548 DOI: 10.19852/j.cnki.jtcm.20240203.002
Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis.
J Tradit Chin Med 44(2):408-416
Authors: L I Zhenxuan, Wang Xuerui, Luis Ulloa, Ayman Youssef, Bai Yunjing, X U Xiaolong, Liu Qingquan
Affiliations
- Department of Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China. 2 Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing 100010, China. 3 Infection immunity laboratory, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China. 4 Clinical College of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
- Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Abstract
Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation. Increasing evidence suggests that complementary and alternative medicine, especially Traditional Chinese Medicine (TCM), is favorable in alleviating cognitive decline after sepsis. Here, we summarized the studies of traditional herbal remedies, TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.
MeSH
Complementary Therapies, Blood-Brain Barrier, Cognition Disorders, Medicine, East Asian Traditional, Cognitive Dysfunction, Sepsis-Associated Encephalopathy