Journal Article Ppublish 1 citation
PubMed: 38513145 DOI: 10.1177/03000605241235848
Reduced cerebral blood flow and cognitive dysfunction following isolated cerebellar infarction: two case reports.
J Int Med Res 52(3):3000605241235848
Authors: Qi Liu, Yingkui Zhang, Chang Liu, Yu Chen, Yumei Zhang
Affiliations
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, USA.
- Department of Rehabilitation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Abstract
Cognitive impairment in focal cerebellar disorders has been widely recognized and is described as cerebellar cognitive affective syndrome (CCAS). However, the relationship between CCAS and crossed cerebello-cerebral diaschisis (CCD) has rarely been discussed. The present report describes the uncommon phenomenon of CCD in two cases with isolated cerebellar infarction, and discuss its contribution to cognitive impairment. Cognitive performance was examined using the CCAS scale and a battery of neuropsychological assessments. Moreover, the relative distribution of cerebral and cerebellar blood flow was measured using three-dimensional arterial spin labeling imaging. Case 1 showed deficits in general cognition and had impaired language, episodic memory, and executive function. Case 2 showed deficits in general cognition at baseline, and cognitive deterioration of visuospatial abilities, language, episodic memory, and executive function was observed at the 3-month follow-up. Both cases met the diagnosis criteria of CCAS. Reduced cerebral blood flow was observed in the cerebral hemisphere contralateral to the cerebellar infarction at baseline in Case 1, and at the 3-month follow-up in Case 2. The present report describes cognitive decline after isolated cerebellar infarction in combination with contralateral cerebral hypoperfusion, as measured using quantitative arterial spin labeling. One possible mechanism involves the functional depression of cerebello-cerebral pathways.
MeSH
Language, Executive Function, Cognitive Dysfunction, Pharmacology, Cognition Disorders, Research, Blood Circulation, Memory, Episodic