Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Ppublish
PubMed: 38525671 DOI: 10.1017/S1355617724000146
Determinants of confrontation naming deficits on the Boston Naming Test associated with transactive response DNA-binding protein 43 pathology.
J Int Neuropsychol Soc 30(6):575-583
Authors: Carling G Robinson, Austin W Goodrich, Stephen D Weigand, Nha Trang Thu Pham, Arenn F Carlos, Marina Buciuc, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, David S Knopman, Ronald C Petersen, Dennis W Dickson, Rene L Utianski, Jennifer L Whitwell, Keith A Josephs, Mary M Machulda
Affiliations
- Department of Neurology, Mayo Clinic, Rochester, MN, USA.
- Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
- Department of Radiology, Mayo Clinic, Rochester, MN, USA.
- Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
- Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
- Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Abstract
OBJECTIVE
To determine whether poorer performance on the Boston Naming Test (BNT) in individuals with transactive response DNA-binding protein 43 pathology (TDP-43+) is due to greater loss of word knowledge compared to retrieval-based deficits.
METHODS
Retrospective clinical-pathologic study of 282 participants with Alzheimer's disease neuropathologic changes (ADNC) and known TDP-43 status. We evaluated item-level performance on the 60-item BNT for first and last available assessment. We fit cross-sectional negative binomial count models that assessed total number of incorrect items, number correct of responses with phonemic cue (reflecting retrieval difficulties), and number of "I don't know" (IDK) responses (suggestive of loss of word knowledge) at both assessments. Models included TDP-43 status and adjusted for sex, age, education, years from test to death, and ADNC severity. Models that evaluated the last assessment adjusted for number of prior BNT exposures.
RESULTS
43% were TDP-43+. The TDP-43+ group had worse performance on BNT total score at first (p = .01) and last assessments (p = .01). At first assessment, TDP-43+ individuals had an estimated 29% (CI: 7%-56%) higher mean number of incorrect items after adjusting for covariates, and a 51% (CI: 15%-98%) higher number of IDK responses compared to TDP-43-. At last assessment, compared to TDP-43-, the TDP-43+ group on average missed 31% (CI: 6%-62%; p = .01) more items and had 33% more IDK responses (CI: 1% fewer to 78% more; p = .06).
CONCLUSIONS
An important component of poorer performance on the BNT in participants who are TDP-43+ is having loss of word knowledge versus retrieval difficulties.
MeSH
Pathology, Dna-Binding Proteins, Nervous System Diseases, Neuropsychology, Tdp-43 Proteinopathies, Language Tests