Journal Article Review Epublish 34 citations
PubMed: 38534355 DOI: 10.3390/cells13060511
Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.
Cells 13(6)
Authors: Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Affiliations
- Institute for Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA.
- Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA.
- Miami VA Geriatric Research Education and Clinical Center (GRECC), Miami Veterans Affairs Healthcare System, Miami, FL 33125, USA.
- Cell Therapy Institute, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA.
- Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins. Activation of glial cells and immune cells leads to the release of many inflammatory and neurotoxic molecules that cause neuroinflammation and neurodegeneration. Gulf War Illness (GWI) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic disorders that are also associated with neuroimmune dysfunctions. Currently, there are no effective disease-modifying therapeutic options available for these diseases. Human induced pluripotent stem cell (iPSC)-derived neurons, astrocytes, microglia, endothelial cells and pericytes are currently used for many disease models for drug discovery. This review highlights certain recent trends in neuroinflammatory responses and iPSC-derived brain cell applications in neuroinflammatory disorders.
MeSH
Neurons, Fatigue Syndrome, Chronic, Neuroglia, Blood-Brain Barrier, Neurodegenerative Diseases, Research, Endothelial Cells
Cited by
- Expression of Neuronal Nicotinic Acetylcholine Receptor and Early Oxidative DNA Damage in Aging Rat Brain-The Effects of Memantine. Int J Mol Sci, 2025
- The role of brain-liver-gut Axis in neurological disorders. Burns Trauma, 2025
- The Role of Antioxidant Compounds from Citrus Waste in Modulating Neuroinflammation: A Sustainable Solution. Antioxidants (Basel), 2025
- Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions. Int J Mol Sci, 2025
- Omega-3 Fatty Acids and Neuroinflammation in Depression: Targeting Damage-Associated Molecular Patterns and Neural Biomarkers. Cells, 2024
- Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson's disease-related fatigue. Front Aging Neurosci, 2025
- Longer-term effects and underlying mechanisms of dietary intervention strategies on cognitive performance in adults with cognitive impairment. Curr Opin Clin Nutr Metab Care, 2025
- Effects of Dendrobium officinale Kimura & Migo flower flavonoids on cognitive function by regulating gut microbiota. Front Pharmacol, 2025
- ImmunoMet Oncogenesis: A New Concept to Understand the Molecular Drivers of Cancer. J Clin Med, 2025
- Alterations of the oral microbiota in mild Alzheimer's disease and the appropriate application of chlorhexidine gluconate. JAR Life, 2025
- Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism. Front Pharmacol, 2025
- Alzheimer's, Parkinson's, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine. Toxics, 2025
- Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort. Int J Environ Res Public Health, 2024
- Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury. Invest Ophthalmol Vis Sci, 2025
- Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers. Biosensors (Basel), 2025
- Novel susceptibility genes and biomarkers for obstructive sleep apnea: insights from genetic and inflammatory proteins. Sleep, 2025
- Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation. Ren Fail, 2025
- Potential common pathogenesis of several neurodegenerative diseases. Neural Regen Res, 2025
- Elevated miRNA-21, miRNA-155, and miRNA-182 levels correlate with cytokine dysregulation in neurological disorders and indicate potential for biomarker and therapy development. Sci Rep, 2025
- Role of Long Non-Coding RNA X-Inactive-Specific Transcript (XIST) in Neuroinflammation and Myelination: Insights from Cerebral Organoids and Implications for Multiple Sclerosis. Noncoding RNA, 2025