Journal Article Review Epublish 3 citations
PubMed: 38539202 DOI: 10.1186/s12985-024-02342-w
SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression.
Virol J 21(1):75
Authors: Hosni A M Hussein, Ali A Thabet, Ahmed A Wardany, Ahmed M El-Adly, Mohamed Ali, Mohamed E A Hassan, Mohamed A B Abdeldayem, Abdul-Rahman M A Mohamed, Ali Sobhy, Mohamed A El-Mokhtar, Magdy M Afifi, Samah M Fathy, Serageldeen Sultan
Affiliations
- Department of Microbiology, Faculty of Science, Al-Azhar University, 71524, Assiut, Egypt.
- Department of Zoology, Faculty of Science, Al-Azhar University, 71524, Assiut, Egypt.
- Department of Microbiology, Faculty of Science, Al-Azhar University, 71524, Assiut, Egypt.
- Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, 71524, Assiut, Egypt.
- Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
- Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos Campus, Lebanon.
- Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
- Department of Zoology, Faculty of Science, Fayoum University, Fayoum, Egypt.
- Department of Microbiology, Virology Division, Faculty of Veterinary medicine, South Valley University, 83523, Qena, Egypt.
Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health problem and the disease has now spread to most countries in the world. COVID-19 has profoundly impacted human health and activities worldwide. Genetic mutation is one of the essential characteristics of viruses. They do so to adapt to their host or to move to another one. Viral genetic mutations have a high potentiality to impact human health as these mutations grant viruses unique unpredicted characteristics. The difficulty in predicting viral genetic mutations is a significant obstacle in the field. Evidence indicates that SARS-CoV-2 has a variety of genetic mutations and genomic diversity with obvious clinical consequences and implications. In this review, we comprehensively summarized and discussed the currently available knowledge regarding SARS-CoV-2 outbreaks with a fundamental focus on the role of the viral proteins and their mutations in viral infection and COVID-19 progression. We also summarized the clinical implications of SARS-CoV-2 variants and how they affect the disease severity and hinder vaccine development. Finally, we provided a massive phylogenetic analysis of the spike gene of 214 SARS-CoV-2 isolates from different geographical regions all over the world and their associated clinical implications.
MeSH
Viral Proteins, Infections, Virus Diseases, Virology, Mutation, Genes, Viruses, Coronavirus, Sars Virus, Covid-19, Sars-Cov-2