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Publications

Journal Article Epublish

PubMed: 38549636 DOI: 10.3233/ADR-230102

Associations of Serum Liver Function with Cerebral Blood Flow in Patients with Alzheimer's Disease.

J Alzheimers Dis Rep 8(1):437-445

Authors: Hao Wang, Lin Shi, Shimei Luo, Yishan Luo, Chunyan Xu, Guozhen Qiu, Qiwen Guo, Chunchun Chen, Taikun Lu, Kangding Liu, Feiqi Zhu

Affiliations

  • Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China.
  • BrainNow Research Institute, Guangdong, China.
  • Department of Nuclear Magnetic Resonance, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, China.
  • Cognitive Impairment Ward of Neurology Department, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, China.

Abstract

Background

Increasing evidence suggests that both amyloid-β metabolism disorders in the liver and cerebral hypoperfusion play an important role in the pathogenesis of Alzheimer's disease (AD). However, the relevance of liver function alterations to cerebral blood flow (CBF) of patients with AD remains unclear.

Objective

We aimed to investigate the associations between liver function changes and CBF of patients with AD.

Methods

We recruited 17 patients with sporadic AD. In addition to physical and neurological examinations, detection of AD biomarkers in cerebrospinal fluid by enzyme-linked immunosorbent assay and CBF assessment by arterial spin labeling sequence of magnetic resonance image scans as well as measure of liver function markers in serum by routine laboratory testing were conducted. Neuropsychological tests were evaluated, including Mini-Mental State Examination and Montreal Cognitive Assessment. Linear and rank correlations were performed to test the associations of liver function alterations with regional CBF of AD.

Results

We found that liver function markers, especially total protein, the ratio of albumin to globin, globin, alkaline phosphatase, and aspartate aminotransferase were significantly associated with regional CBF of AD patients.

Conclusions

These findings demonstrated significant associations between perfusion in certain brain regions of AD and alterations of liver function markers, particularly proteins and liver enzymes, which might provide implications to the pathogenesis and treatment of AD.

MeSH

Enzymes, Blood Circulation, Alzheimer Disease, Globins, Liver, Enzyme-Linked Immunosorbent Assay, Serum, Mental Status And Dementia Tests