Journal Article Ppublish 3 citations
PubMed: 38561599 DOI: 10.1021/acs.est.4c00534
Air Pollutants and Mortality Risk in Patients with Aortic Dissection: Evidence from a Clinical Cohort, Single-Cell Sequencing, and Proteomics.
Environ Sci Technol 58(15):6509-6518
Authors: Mengyue Lin, Jingyi Yan, Junshuang Tang, Sirui Han, Pi Guo, Shiwan Wu, Liang Tao, Hongyan Xiao, Yequn Chen, Xuerui Tan
Affiliations
- Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
- Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
- Department of Preventive Medicine, Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
- Department of Cardiac Surgery, Wuhan Asia Heart Hospital Affiliated with Wuhan University of Science and Technology, No. 753 Jinghan Road, Wuhan 430000, China.
- Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China. Clinical Research Center, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
- Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China. Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China. Clinical Research Center, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
Abstract
We aimed to evaluate the association between air pollutants and mortality risk in patients with acute aortic dissection (AAD) in a longitudinal cohort and to explore the potential mechanisms of adverse prognosis induced by fine particulate matter (PM2.5). Air pollutants data, including PM2.5, PM10.0, nitrogen dioxide (NO), carbon monoxide (CO), sulfur dioxide (SO), and ozone (O), were collected from official monitoring stations, and multivariable Cox regression models were applied. Single-cell sequencing and proteomics of aortic tissue were conducted to explore the potential mechanisms. In total, 1,267 patients with AAD were included. Exposure to higher concentrations of air pollutants was independently associated with an increased mortality risk. The high-PM2.5 group carried approximately 2 times increased mortality risk. There were linear associations of PM10, NO, CO, and SO exposures with long-term mortality risk. Single-cell sequencing revealed an increase in mast cells in aortic tissue in the high-PM2.5 exposure group. Enrichment analysis of the differentially expressed genes identified the inflammatory response as one of the main pathways, with IL-17 and TNF signaling pathways being among the top pathways. Analysis of proteomics also identified these pathways. This study suggests that exposure to higher PM2.5, PM10, NO, CO, and SO are associated with increased mortality risk in patients with AAD. PM2.5-related activation and degranulation of mast cells may be involved in this process.
MeSH
Sanitation, Mortality, Dissection, Aneurysm, Dissecting, Risk, Air Pollutants, Mast Cells, Environmental Pollutants, Air Pollution, Environmental Health, Tissues, Proteomics
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