Journal Article Ppublish 18 citations
PubMed: 38566850 DOI: 10.1093/lifemeta/load051
The energetics of cellular life transitions.
Life Metab 3(3)
Authors: Anna S Monzel, Michael Levin, Martin Picard
Affiliations
- Department of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, United States.
- Department of Biology, Tufts University, Medford, MA 02155, United States. Allen Discovery Center at Tufts University, Medford, MA 02155, United States. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States.
- Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, United States.
- New York State Psychiatric Institute, New York, NY 10032, United States.
- Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, United States.
Abstract
Major life transitions are always difficult because change costs energy. Recent findings have demonstrated how mitochondrial oxidative phosphorylation (OxPhos) defects increase the energetic cost of living, and that excessive integrated stress response (ISR) signaling may prevent cellular identity transitions during development. In this perspective, we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift identity. The energetic cost of cellular differentiation has not been directly quantified, representing a gap in knowledge. We propose that the ISR is an energetic checkpoint evolved to i) prevent OxPhos-deficient cells from engaging in excessively costly transitions, and ii) allow ISR-positive cells to recruit systemic energetic resources by signaling via the brain.
MeSH
Cells, Mitochondria
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