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Journal Article Epublish 5 citations

PubMed: 38567194 DOI: 10.1093/ofid/ofae144

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses.

Open Forum Infect Dis 11(4):ofae144

Authors: Susanna E Barouch, Taras M Chicz, Ross Blanc, Domenic R Barbati, Lily J Parker, Xin Tong, Wenjun Li, Ryan P McNamara

Affiliations

  • Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
  • Department of Public Health, Center for Health Statistics and Biostatistics, University of Massachusetts at Lowell. Lowell, Massachusetts, USA.

Abstract

Background

The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains unclear.

Methods

Here, we analyzed antibody responses in health care workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or on different days through systems serology. Antibody-binding and functional responses were characterized at peak responses and after 6 months following vaccination.

Results

IgG1 and neutralization responses to SARS-CoV-2 XBB.1.5 were higher at peak and after 6 months following concurrent administration as compared with separate administration of the COVID-19 and influenza vaccines. While similar results were not observed for influenza responses, no interference was noted with concurrent administration.

Conclusions

These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 neutralizing antibody responses while maintaining responses against influenza.

MeSH

Antibody Formation, Vaccines, Covid-19, Influenza, Human, Influenza Vaccines

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