Journal Article Ppublish
PubMed: 38743370 DOI: 10.1007/978-1-0716-3870-5_13
Setup of Aerosol Delivery System to Prevent Measles Virus Infection in Nonhuman Primate Model.
Methods Mol Biol 2808:167-175
Authors: Olivier Reynard, Jérôme Montharu, Mathieu Iampietro, Claudia Gonzalez, Sandrine Le Guellec, Branka Horvat, Laurent Vecellio
Affiliations
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France.
- PST-A, University of Tours, Tours, France.
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France.
- Faculté de médecine, DTF-Aerodrug, R&D Aerosoltherapy Department of DTF medical (Saint Etienne, France), Université de Tours, Tours, France.
Abstract
Measles virus is one of the most contagious airborne human viruses which keeps causing outbreaks in numerous countries over the world despite the existence of an efficient vaccine. Fusion inhibitory lipopeptides were shown to inhibit viral entry into target cells, and their adequate administration into the respiratory tract may provide a novel preventive approach against airborne infections. Aerosol delivery presents the best administration route to deliver such preventive compounds to the upper and lower respiratory tract. This approach offers a conceptually new strategy to protect the population at risk against infection by respiratory viruses, including measles. It is a noninvasive needle-free approach, which may be used when antiviral protection is required, without any medical assistance. In this chapter, we describe the nebulization approach of lipopeptide compounds in nonhuman primates and the subsequent measles virus challenge.
MeSH
Lipopeptides, Aerosols, Measles Virus, Viruses, Infections, Virus Diseases