Journal Article Review Epublish 6 citations
PubMed: 38773621 DOI: 10.1186/s12967-024-05176-w
Adherence to the Mediterranean Diet and its association with gastric cancer: health benefits from a Planeterranean perspective.
J Transl Med 22(1):483
Authors: Claudia Reytor-González, Ana Karina Zambrano, Martha Montalvan, Evelyn Frias-Toral, Alison Simancas-Racines, Daniel Simancas-Racines
Affiliations
- Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, 170129, Quito, Ecuador.
- Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Mariana de Jesús Ave, no number, 170129, Quito, Pichincha, Ecuador.
- Universidad Católica Santiago de Guayaquil, . Pdte. Carlos Julio Arosemena Tola, 090615, Guayaquil, Ecuador.
- School of Medicine, Universidad Católica Santiago de Guayaquil, Guayas, Guayaquil, Ecuador.
- Escuela de Medicina, Universidad Espíritu Santo, 0901952, Samborondón, Ecuador.
- Carrera de Medicina Veterinaria, Facultad de Ciencias Agropecuarias y Recursos Naturales, Universidad Técnica de Cotopaxi, 050108, Latacunga, Ecuador.
- Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, 170129, Quito, Ecuador.
Abstract
The Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC). The MD's rich content of antioxidants, polyphenols, and other bioactive compounds contributes to its ability to modulate gene expression, inhibit tumor growth, and regulate apoptosis. Studies have shown significant reductions in inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) among individuals adhering to the MD, suggesting its pivotal role in mitigating chronic inflammation-associated with cancer development. Furthermore, the MD's anti-angiogenic properties, particularly in components like olive oil, red wine, fish, and tomatoes, offer promising avenues for reducing GC risk by inhibiting tumor angiogenesis. Additionally, the MD's influence on intestinal microbiota composition underscores its potential in maintaining immune homeostasis and reducing systemic inflammation, factors crucial in GC prevention. Despite challenges such as variability in dietary adherence scoring systems and the need for further gender and geographical-specific studies, evidence supports the MD as a cost-effective and holistic approach to GC prevention. Emphasizing the role of nutrition in public health is a promising strategy with broad implications for global health and cancer prevention initiatives. Therefore, this review explores the multifaceted impacts of the MD on GC prevention, delving into its anti-inflammatory, anti-angiogenic, and molecular mechanisms.
MeSH
Genes, Tumor Necrosis Factor-Alpha, Biomedical Research, Neoplasms, Interleukin-6, Diet, Mediterranean, Diet, Stomach Neoplasms
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- Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway. Drug Des Devel Ther, 2025
- Adherence to Mediterranean Diet and Breast Cancer Risk: A Meta-Analysis of Prospective Observational Studies. Health Sci Rep, 2025
- Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response. Int J Mol Sci, 2025
- Chrononutrition and Energy Balance: How Meal Timing and Circadian Rhythms Shape Weight Regulation and Metabolic Health. Nutrients, 2025
- Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses. Front Oncol, 2025