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Publications

Journal Article Epublish 1 citation

PubMed: 38789537 DOI: 10.1038/s41598-024-62500-6

A novel transcranial MR Guided focused ultrasound method based on the ultrashort echo time skull acoustic model and phase retrieval techniques.

Sci Rep 14(1):11876

Authors: Dechen Kong, Gaojie Liu, Bochao Cheng, Xu Qi, Jiayu Zhu, Qiang He, Haoyang Xing, Qiyong Gong

Affiliations

  • College Of Physics, Sichuan University, Chengdu, China. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
  • Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China. Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, 610041, China.
  • Radiotherapy Physics & Technology Center, Cancer Center, West China Hospital of Sichuan University, Chengdu, 610041, China.
  • Central Research Institute, United Imaging Healthcare Group, Shanghai, China.
  • College Of Physics, Sichuan University, Chengdu, China. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China. Xiamen West China Hospital, Sichuan University, Xiamen, China.
  • Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China. Xiamen West China Hospital, Sichuan University, Xiamen, China.

Abstract

Transcranial ultrasound stimulation (TUS) has been clinically applied as a neuromodulation tool. Particularly, the phase array ultrasound can be applied in TUS to non-invasively focus on the cortex or deep brain. However, the vital phase distortion of the ultrasound induced by the skull limits its clinical application. In the current study, we aimed to develop a hybrid method that combines the ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequences with the prDeep technique to achieve focusing ventral intermediate thalamic nucleus (VIM). The time-reversal (TR) approach of the UTE numerical acoustic model of the skull combined with the prDeep algorithm was used to reduce the number of iterations. The skull acoustic model simulation therapy process was establish to valid this method's prediction and focus performance, and the classical TR method were considered as the gold standard (GS). Our approach could restore 75% of the GS intensity in 25 iteration steps, with a superior the noise immunity. Our findings demonstrate that the phase aberration caused by the skull can be estimated using phase retrieval techniques to achieve a fast and accurate transcranial focus. The method has excellent adaptability and anti-noise capacity for satisfying complex and changeable scenarios.

MeSH

Natural Science Disciplines, Acoustics