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Publications

Journal Article Review Research Support, Non-U.S. Gov't Ppublish 1 citation

PubMed: 38835218 DOI: 10.1080/21645515.2024.2351675

The economic rationale for cell-based influenza vaccines in children and adults: A review of cost-effectiveness analyses.

Hum Vaccin Immunother 20(1):2351675

Authors: David Fisman, Norberto Giglio, Myron J Levin, Van Hung Nguyen, Stephen I Pelton, Maarten Postma, Jesús Ruiz-Aragón, Analia Urueña, Joaquin F Mould-Quevedo

Affiliations

  • Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
  • Servicio de Consultorios Externos de Pediatría. Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
  • Departments of Pedatrics and Medicine, University of Colorado School of Medicine, Denver, Colorado, United States.
  • VNH Consulting, Montreal, Québec, Canada.
  • Department of Health Sciences, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
  • Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.
  • Faculty of Economics & Business, University of Groningen, Groningen, The Netherlands.
  • Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Hospital de la Línea de la Concepción, Cádiz, Spain.
  • Centro de Estudios para la Prevención y Control de Enfermedades Transmisibles, Universidad Isalud, Buenos Aires, Argentina.
  • CSL Seqirus Inc. Summit, New Jersey, USA.

Abstract

Seasonal influenza significantly affects both health and economic costs in children and adults. This narrative review summarizes published cost-effectiveness analyses (CEAs) of cell-based influenza vaccines in children and adults <65 years of age, critically assesses the assumptions and approaches used in these analyses, and considers the role of cell-based influenza vaccines for children and adults. CEAs from multiple countries demonstrated the cost-effectiveness of cell-based quadrivalent influenza vaccines (QIVc) compared with egg-based trivalent/quadrivalent influenza vaccines (TIVe/QIVe). CEA findings were consistent across models relying on different relative vaccine effectiveness (rVE) estimate inputs, with the rVE of QIVc versus QIVe ranging from 8.1% to 36.2% in favor of QIVc. Across multiple scenarios and types of analyses, QIVc was consistently cost-effective compared with QIVe, including in children and adults across different regions of the world.

MeSH

Child, Influenza, Human, Influenza Vaccines, Cells

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