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Journal Article Ppublish 5 citations

PubMed: 38873833 DOI: 10.1093/inthealth/ihae039

Risk factors associated with multidrug-resistant tuberculosis in areas with a moderate tuberculosis burden.

Int Health 17(2):186-194

Authors: Noormohamad Mansoori, Bagher Pahlavanzadeh, Masoumeh Atarjalali

Affiliations

  • Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran.
  • Research Center for Environmental Contaminants, Abadan University of Medical Sciences, Abadan, Iran.
  • Department of Health, Golestan University of Medical Sciences, Gorgan, Iran.

Abstract

BACKGROUND

The emergence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant (RR) TB poses a significant challenge for TB control initiatives on a global scale. This study's aim was to estimate the incidence of MDR-/RR-TB and identify the risk factors associated with their incidence in four provinces in northern Iran.

METHODS

Drug susceptibility testing was conducted using the proportion method on Lowenstein-Jensen media. The demographic and clinical data were collected from the Iranian TB registry.

RESULTS

Among 1083 individuals diagnosed with TB, 27 (2.5%) were identified as having MDR-/RR-TB, while 73 cases (6.7%) were any drug resistant (ADR). The statistical analysis revealed a significant association between marital status and MDR-/RR-TB (p=0.003). In addition, significant associations were observed between ADR-TB and gender (p=0.035) and previous treatment for TB (p=0.02).

CONCLUSIONS

Our findings provide important information on the drug resistance pattern of Mycobacterium tuberculosis strains, as well as risk factors in northern Iran. Given the identified risk factors, creative approaches to promote treatment adherence in TB patients, particularly divorced/widowed women and individuals with a previous history of TB treatment, are required.

MeSH

Tuberculosis, Multidrug-Resistant, Incidence, Pharmaceutical Preparations, Tuberculosis, Risk Factors, Therapeutics

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