English Abstract Journal Article Ppublish 2 citations
PubMed: 38926376 DOI: 10.7499/j.issn.1008-8830.2401048
[Neurodevelopment and cerebral blood flow in children aged 2-6 years with autism spectrum disorder].
Zhongguo Dang Dai Er Ke Za Zhi 26(6):599-604
Authors: Jia-Bao Yin, Gan-Yu Wang, Gui-Qin Duan, Wen-Hao Nie, Ming-Fang Zhao, Ting-Ting Jin
Affiliations
- Department of Child Health Care/Child Psychology and Behavior Center, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Abstract
OBJECTIVES
To investigate the neurodevelopmental characteristics of children with autism spectrum disorder (ASD), analyze the correlation between neurodevelopmental indicators and cerebral blood flow (CBF), and explore the potential mechanisms of neurodevelopment in ASD children.
METHODS
A retrospective study was conducted on 145 children aged 2-6 years with newly-diagnosed ASD. Scores from the Gesell Developmental Diagnosis Scale and the Autism Behavior Checklist (ABC) and CBF results were collected to compare gender differences in the development of children with ASD and analyze the correlation between CBF and neurodevelopmental indicators.
RESULTS
Fine motor and personal-social development quotient in boys with ASD were lower than those in girls with ASD (<0.05). Gross motor development quotient in ASD children was negatively correlated with CBF in the left frontal lobe (=-0.200, =0.016), right frontal lobe (=-0.279, =0.001), left parietal lobe (=-0.208, =0.012), and right parietal lobe (=-0.187, =0.025). The total ABC score was positively correlated with CBF in the left amygdala (=0.295, <0.001).
CONCLUSIONS
Early intervention training should pay attention to gender and developmental structural characteristics for precise intervention in ASD children. CBF has the potential to become a biological marker for assessing the severity of ASD.
MeSH
Frontal Lobe, Autism Spectrum Disorder, Blood, Autistic Disorder, Aged, Parietal Lobe, Pediatrics, Blood Circulation, Child, Neurodevelopment