Journal Article Review Research Support, Non-U.S. Gov't Epublish 1 citation
PubMed: 39066259 DOI: 10.3390/v16071097
Translation Inhibition Mediated by Interferon-Stimulated Genes during Viral Infections.
Viruses 16(7)
Authors: Alexandria Smart, Orian Gilmer, Neva Caliskan
Affiliations
- Helmholtz Institute for RNA-Based Infection Research, Helmholtz Centre for Infection Research (HIRI-HZI), Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.
- Regensburg Center for Biochemistry (RCB), University of Regensburg, 93053 Regensburg, Germany.
Abstract
Viruses often pose a significant threat to the host through the exploitation of cellular machineries for their own benefit. In the context of immune responses, myriad host factors are deployed to target viral RNAs and inhibit viral protein translation, ultimately hampering viral replication. Understanding how "non-self" RNAs interact with the host translation machinery and trigger immune responses would help in the development of treatment strategies for viral infections. In this review, we explore how interferon-stimulated gene products interact with viral RNA and the translation machinery in order to induce either global or targeted translation inhibition.
MeSH
Genes, Virology, Immunity, Infections, Virus Diseases