Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Ppublish 4 citations
PubMed: 39092750 DOI: 10.1002/iid3.1343
Post-COVID pulmonary injury in K18-hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation.
Immun Inflamm Dis 12(8):e1343
Authors: Stefanos Giannakopoulos, Juwon Park, Jin Pak, Michelle D Tallquist, Saguna Verma
Affiliations
- Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
- Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
- Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
Abstract
The involvement of neutrophils in the lungs during the recovery phase of coronavirus disease 2019 (COVID-19) is not well defined mainly due to the limited accessibility of lung tissues from COVID-19 survivors. The lack of an appropriate small animal model has affected the development of effective therapeutic strategies. We here developed a long COVID mouse model to study changes in neutrophil phenotype and association with lung injury. Our data shows persistent neutrophil recruitment and neutrophil extracellular trap formation in the lungs for up to 30 days post-infection which correlates with lung fibrosis and inflammation.
MeSH
Lung, Lung Injury, Neutrophils, Immunity, Cellular, Covid-19, Pulmonary Fibrosis, Immune System Diseases, Extracellular Traps
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- Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies. Front Immunol, 2025
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