Journal Article Review Research Support, N.I.H., Extramural Ppublish 2 citations
PubMed: 39181733 DOI: 10.1016/j.it.2024.07.008
Unmasking the hidden impact of viruses on tuberculosis risk.
Trends Immunol 45(9):649-661
Authors: Fatoumatta Darboe, Josephine F Reijneveld, David P Maison, Leonardo Martinez, Sara Suliman
Affiliations
- Zuckerberg San Francisco General Hospital, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
- Boston University School of Public Health, Department of Epidemiology, Boston, MA, USA.
- Zuckerberg San Francisco General Hospital, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Abstract
Tuberculosis (TB) is a leading cause of mortality from an infectious disease. In this opinion article, we focus on accumulating scientific evidence indicating that viral infections may contribute to TB progression, possibly allowing novel preventive interventions. Viruses can remodel the mammalian immune system, potentially modulating the risk of reactivating latent microbes such as Mycobacterium tuberculosis (Mtb). Evidence is mixed regarding the impact of emergent viruses such as SARS-CoV-2 on the risk of TB. Therefore, we posit that important knowledge gaps include elucidating which viral families increase TB risk and whether these provide unique or shared immune mechanisms. We also propose potential future research to define the contribution of viruses to TB pathogenesis.
MeSH
Cytomegalovirus, Tuberculosis, Viruses, Immunity
Cited by
- Prevalence of Long COVID in exposed Groups in Peru and Kenya. medRxiv, 2025
- Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study. Lancet Child Adolesc Health, 2024