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Publications

Journal Article Epublish

PubMed: 39191763 DOI: 10.1038/s41541-024-00948-3

Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.

NPJ Vaccines 9(1):156

Authors: Lin Li, Yusuke Matsui, Mary K Prahl, Arianna G Cassidy, Yarden Golan, Unurzul Jigmeddagva, Nida Ozarslan, Christine Y Lin, Sirirak Buarpung, Veronica J Gonzalez, Megan A Chidboy, Emilia Basilio, Kara L Lynch, Dongli Song, Priya Jegatheesan, Daljeet S Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Taha Y Taha, Mauricio Montano, Melanie Ott, Warner C Greene, Stephanie L Gaw

Affiliations

  • Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Gladstone Institute of Virology, San Francisco, CA, USA.
  • Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA.
  • Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
  • Division of Pediatric Infectious Diseases and Global Health, University of California San Francisco, San Francisco, CA, USA.
  • Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Division of Neonatology, Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, CA, USA.
  • Stanford-O'Connor Family Medicine Residency Program, Division of Family Medicine, Stanford University, Palo Alto, CA, USA.
  • Division of Neonatology, Department of Pediatrics, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA.
  • Department of Obstetrics and Gynecology, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA.
  • Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
  • Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
  • Gladstone Institute of Virology, San Francisco, CA, USA.
  • Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA.
  • Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
  • Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.

Abstract

Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy.

MeSH

Pregnancy, Antibody Formation, Sars-Cov-2, Vaccines, Antibodies, Vaccination, Immunity, Severe Acute Respiratory Syndrome-Related Coronavirus, Infections

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