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Journal Article Review Research Support, Non-U.S. Gov't Epublish 4 citations

PubMed: 39195210 DOI: 10.3390/cells13161321

Skin Telocytes Could Fundament the Cellular Mechanisms of Wound Healing in Platelet-Rich Plasma Administration.

Cells 13(16)

Authors: Catalin G Manole, Vlad M Voiculescu, Cristina Soare, Laura Cristina Ceafalan, Mihaela Gherghiceanu, Mihail E Hinescu

Affiliations

  • Department of Cellular and Molecular Biology and Histology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Ultrastructural Pathology Laboratory, "Victor BabeÈ™" National Institute of Pathology, 050096 Bucharest, Romania.
  • Department of Oncological Dermatology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Cell Biology, Neurosciences and Experimental Myology Laboratory, "Victor BabeÈ™" National Institute of Pathology, 050096 Bucharest, Romania.
  • "Victor BabeÈ™" National Institute of Pathology, 050096 Bucharest, Romania.

Abstract

For more than 40 years, autologous platelet concentrates have been used in clinical medicine. Since the first formula used, namely platelet-rich plasma (PRP), other platelet concentrates have been experimented with, including platelet-rich fibrin and concentrated growth factor. Platelet concentrates have three standard characteristics: they act as scaffolds, they serve as a source of growth factors and cytokines, and they contain live cells. PRP has become extensively used in regenerative medicine for the successful treatment of a variety of clinical (non-)dermatological conditions like alopecies, acne scars, skin burns, skin ulcers, muscle, cartilage, and bone repair, and as an adjuvant in post-surgery wound healing, with obvious benefits in terms of functionality and aesthetic recovery of affected tissues/organs. These indications were well documented, and a large amount of evidence has already been published supporting the efficacy of this method. The primordial principle behind minimally invasive PRP treatments is the usage of the patient's own platelets. The benefits of the autologous transplantation of thrombocytes are significant, representing a fast and economic method that requires only basic equipment and training, and it is biocompatible, thus being a low risk for the patient (infection and immunological reactions can be virtually disregarded). Usually, the structural benefits of applying PRP are attributed to fibroblasts only, as they are considered the most numerous cell population within the interstitium. However, this apparent simplistic explanation is still eluding those different types of interstitial cells (distinct from fibroblasts) that are residing within stromal tissue, e.g., telocytes (TCs). Moreover, dermal TCs have an already documented potential in angiogenesis (extra-cutaneous, but also within skin), and their implication in skin recovery in a few dermatological conditions was attested and described ultrastructurally and immunophenotypically. Interestingly, PRP biochemically consists of a series of growth factors, cytokines, and other molecules, to which TCs have also proven to have a positive expression. Thus, it is attractive to hypothesize and to document any tissular collaboration between cutaneous administered PRP and local dermal TCs in skin recovery/repair/regeneration. Therefore, TCs could be perceived as the missing link necessary to provide a solid explanation of the good results achieved by administering PRP in skin-repairing processes.

MeSH

Platelet-Rich Plasma, Cytokines, Skin, Cells, Growth, Recycling, Telocytes, Fibroblasts, Therapeutics, Blood Platelets, Tissues, Platelet-Rich Fibrin, Dermatology, Plasma

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