Journal Article Research Support, Non-U.S. Gov't Ppublish 3 citations
PubMed: 39325679 DOI: 10.1080/17435889.2024.2393071
Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer.
Nanomedicine (Lond) 19(27):2257-2270
Authors: Ramezan Ali Taheri, Hamidreza Fathi, Ali Sharafi, Morteza Mirzaei, Shima Jafari, Mohammad Hasan Darvishi
Affiliations
- Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
- Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
- Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
- Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
- Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Abstract
Aim: The present investigation aimed to develop niosomes containing gold nanoparticles (Nio-AuNPs) and to evaluate the combinational effect of Nio-AuNPs and x-ray radiation therapy (XRT) on growth inhibition potential and induction of apoptosis in the A549 cell line.Materials & methods: Gold nanoparticles (AuNPs) were synthesized, and niosomes were prepared using the thin-film hydration method. Various techniques were employed to determine their physiochemical characteristics. MTT assay, cell apoptosis analysis and combination index analysis were conducted to evaluate the therapeutic feasibility of Nio-AuNPs combined with XRT.Results: The combination of Nio-AuNPs and XRT resulted in greater cytotoxicity compared with XRT alone or with AuNPs.Conclusion: The AuNPs-loaded niosomal formulation enhances the efficacy of XRT on lung cancer cells in vitro, presenting a promising and effective therapeutic strategy.
MeSH
Radiotherapy, Cells, A549 Cells, Lung, Nanomedicine, Nanoparticles, Neoplasms, Lung Neoplasms, Therapeutics, Apoptosis
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- Targeting Cancer Cell Fate: Apoptosis, Autophagy, and Gold Nanoparticles in Treatment Strategies. Curr Issues Mol Biol, 2025
- Preparation and characterization of niosomes containing silver nanoparticles as a radiosensitizer for enhancing radiotherapy of the lung cancer. Sci Rep, 2025