Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Epublish 6 citations
PubMed: 39402481 DOI: 10.1186/s12871-024-02762-9
Value of narcotrend anesthesia depth monitoring in predicting POCD in gastrointestinal tumor anesthesia block patients.
BMC Anesthesiol 24(1):371
Authors: Xizhong Ma, Xueli Zhao, Ruina Guo, Zhixun Hu, Jianghong Liu, Hongfeng Nie
Affiliations
- Department of Gastrointestinal Surgery, The First Hospital of Xingtai, No. 376, Shunde Road, Xiangdu District, Xingtai, 054000, China.
- Department of Anesthesiology, The First Hospital of Xingtai, Xingtai, 054000, China.
- Department of CTMRI, North China Medical and Health Group Xingtai General Hospital, Xingtai, 054099, China.
- Department of Gastrointestinal Surgery, The First Hospital of Xingtai, No. 376, Shunde Road, Xiangdu District, Xingtai, 054000, China.
Abstract
BACKGROUND
The purpose of this research was to evaluate the efficacy of Narcotrend (NT) monitoring on cognitive dysfunction in patients undergoing anesthesia blockade for gastrointestinal tumors and its effect on cerebral oxygen metabolism and inflammatory response.
METHODS
Patients preparing to undergo resection of gastrointestinal tumor resection were included and randomly divided into a control group (depth of anesthesia assessed by physician experience) and a research group (depth of anesthesia monitored by NT). HR and MAP were monitored at the preoperatively (T), 12 h postoperative (T), 24 h postoperative (T), and 48 h postoperative (T) stages. MMSE score was recorded to assess changes in cognitive function. Intracerebral oxygenation indicators (CjvO, CERO and rSO) were assessed by a blood gas analyzer. ELISA assay was conducted to explore the serum inflammatory indexes (CRP, IL-1β, and TNF-α) and neurological function indicators (NSE and MBP).
RESULTS
MAP was higher in the research group than in the control group at T and T (P < 0.05). MMSE scores at T1, T2, and T3 stages were higher in the research group than in the control (P < 0.05). The incidence of POCD was also lower in the research group compared with the control (P < 0.05). CjvO, CERO and rSO were significantly higher (P < 0.05) and were positively correlated with the MMSE scores. Postoperative serum inflammatory indexes were significantly elevated in both groups, but more significantly in the control group (P < 0.05). Both neurological function indicators were usually reduced after surgery, but the reduction was more significant in the research group (P < 0.05).
CONCLUSION
NT monitoring of anesthetic depth has a less physical impact on patients with gastrointestinal tumor anesthetic block, reduces the degree of postoperative POCD, and has significant clinical value.
MeSH
Anesthesia, Serum, Neoplasms, Anesthetics, Research