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Publications

Journal Article Review Epublish 2 citations

PubMed: 39409962 DOI: 10.3390/cancers16193342

Impact of the Lung Microbiota on Development and Progression of Lung Cancer.

Cancers (Basel) 16(19)

Authors: Amine Belaid, Barnabé Roméo, Guylène Rignol, Jonathan Benzaquen, Tanguy Audoin, Valérie Vouret-Craviari, Patrick Brest, Raphaëlle Varraso, Martin von Bergen, Charles Hugo Marquette, Sylvie Leroy, Baharia Mograbi, Paul Hofman

Affiliations

  • Université Côte d'Azur, Institute for Research on Ageing and Cancer, Nice (IRCAN), Institut Hospitalo Universitaire (IHU) RespirERA, Fédérations Hospitalo-Universitaires (FHU) OncoAge, Centre Antoine Lacassagne, Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), 06107 Nice, France.
  • Laboratory of Clinical and Experimental Pathology (LPCE), Biobank (BB-0033-00025), Centre Hospitalier Universitaire (CHU) de Nice, FHU OncoAge, IHU RespirERA, 06000 Nice, France.
  • Centre Hospitalier Universitaire (CHU) de Nice, Department of Pulmonary Medicine and Thoracic Oncology, FHU OncoAge, IHU RespirERA, 06000 Nice, France.
  • Université Paris-Saclay, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, INSERM, 94800 Villejuif, France.
  • Helmholtz Centre for Environmental Research GmbH-UFZ, Department of Molecular Systems Biology, Institute of Biochemistry, Faculty of Life Sciences, University of Leipzig, 04109 Leipzig, Germany.
  • Université Côte d'Azur, Institute for Research on Ageing and Cancer, Nice (IRCAN), Institut Hospitalo Universitaire (IHU) RespirERA, Fédérations Hospitalo-Universitaires (FHU) OncoAge, Centre Antoine Lacassagne, Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), 06107 Nice, France. Centre Hospitalier Universitaire (CHU) de Nice, Department of Pulmonary Medicine and Thoracic Oncology, FHU OncoAge, IHU RespirERA, 06000 Nice, France.

Abstract

The past several years have provided a more profound understanding of the role of microbial species in the lung. The respiratory tract is a delicate ecosystem of bacteria, fungi, parasites, and viruses. Detecting microbial DNA, pathogen-associated molecular patterns (PAMPs), and metabolites in sputum is poised to revolutionize the early diagnosis of lung cancer. The longitudinal monitoring of the lung microbiome holds the potential to predict treatment response and side effects, enabling more personalized and effective treatment options. However, most studies into the lung microbiota have been observational and have not adequately considered the impact of dietary intake and air pollutants. This gap makes it challenging to establish a direct causal relationship between environmental exposure, changes in the composition of the microbiota, lung carcinogenesis, and tumor progression. A holistic understanding of the lung microbiota that considers both diet and air pollutants may pave the way to improved prevention and management strategies for lung cancer.

MeSH

Lung, Environmental Pollutants, Neoplasms, Diet, Air, Immune Checkpoint Inhibitors, Lung Neoplasms, Probiotics, Therapeutics, Air Pollutants, Exposome, Microbiota

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