Journal Article Meta-Analysis Epublish 8 citations
PubMed: 39438699 DOI: 10.1038/s41598-024-76896-8
Association of endometrial cancer risk with hypertension- an updated meta-analysis of observational studies.
Sci Rep 14(1):24884
Authors: Agnieszka Drab, Wiesław Kanadys, Maria Malm, Krystian Wdowiak, Joanna Dolar-Szczasny, Bartłomiej Barczyński
Affiliations
- Chair of Preclinical Science, Department of Medical Informatics and Statistics with e-Health Lab, Medical University of Lublin, K. Jaczewskiego 5 Street, 20-059, Lublin, Poland.
- Specialistic Medical Center Czechow, Lublin, Poland.
- Chair of Preclinical Science, Department of Medical Informatics and Statistics with e-Health Lab, Medical University of Lublin, K. Jaczewskiego 5 Street, 20-059, Lublin, Poland.
- Faculty of Medicine, Medical University of Lublin, Lublin, Poland.
- Department of General and Pediatric Ophtalmology, Medical University of Lublin, 20-079, Lublin, Poland.
- I Chair, Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Lublin, Poland.
Abstract
Endometrial cancer is one of the most common gynaecological cancers in the developed countries. The aim of this study was to determine the impact of hypertension on endometrial cancer risk. Databases: PubMed, Embase and the Cochrane Library were searched from January 2000 to June 2024. We used DerSimonian-Laird random-effects model for analysis. Risk estimates were extracted by two authors and summarized using meta-analytic methods. A total of 26 observational studies with 207,502 endometrial cancer cases were included in the study. Overall meta-analysis demonstrates significant association between hypertension and endometrial cancer risk (RR = 1.37, 95% CI: 1.27-1.47, p < 0.001). Subgroup analysis of the risk of endometrial cancer shows statistically significant higher risk in patients with BMI ≥ 30 kg/m2, diabetics, women who had their first menstrual period at the age of 11 years or earlier, and who had never given birth. Findings of this comprehensive review and meta-analysis indicate that hypertension is associated with higher overall risk of endometrial cancer.
MeSH
Hypertension, Neoplasms, Natural Science Disciplines, Endometrial Neoplasms