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Journal Article Multicenter Study Comparative Study Ppublish 1 citation

PubMed: 39442326 DOI: 10.1016/j.jpedsurg.2024.161991

Congenital Diaphragmatic Eventration: Should we Maintain Surgical Treatment? A Retrospective Multicentric Cohort Study.

J Pediatr Surg 60(1):161991

Authors: Lymeymey Heng, Khalid Alzahrani, Louise Montalva, Guillaume Podevin, Françoise Schmitt

Affiliations

  • Pediatric Surgery Unit, Federation of Pediatrics, University Hospital Centre, Angers, France.
  • Pediatric Surgery Department, Robert Debré Hospital, AP-HP, Paris, France.
  • Pediatric Surgery Unit, Federation of Pediatrics, University Hospital Centre, Angers, France.

Abstract

BACKGROUND

The aims of this study were to describe the characteristics of children with congenital diaphragmatic eventration (CDE) and compare the outcomes of surgical and conservative treatment of pediatric CDE in France.

METHODS

Retrospective study on cohort data conducted in 22 paediatric surgery departments, including patients less than 16 years of age diagnosed with CDE between 2010 and 2021. Patients with surgical or conservative treatment were compared.

RESULTS

139 patients were included, with a median age of 8 [1-16] months. CDE occurred in boys in 68.3% and was right-sided in 66.7% of the cases. Indication for treatment depended essentially on respiratory symptoms and level of the diaphragmatic dome. The initial treatment was a surgical, with a diaphragmatic plication, in 87 cases (62%) and conservative, consisting of clinical follow-up in 52 children (38%). Of the latter, 25 children underwent surgery secondarily. Intra- and early post-operative complications occurred in 32 children (29%) and eventration recurrence in 8 children (7%). With a median follow-up of 28 months, the median level of diaphragmatic dome improved from the 6th to the 9th back rib, and the rate of respiratory symptoms decreased from 64% to 14% in the overall cohort of patients.

CONCLUSIONS

Diaphragmatic plication is effective in symptomatic patients with a dome level above the 6th posterior rib, but is associated with a 29% complication rate and 7% of recurrence.

CLINICALTRIALS

NCT04862494, April 28, 2021.

LEVEL OF EVIDENCE

level III treatment study.

MeSH

Diaphragmatic Eventration, Conservative Treatment, Cohort Studies, Signs And Symptoms, Therapeutics, Pediatrics, General Surgery, Child

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