Journal Article Review Ppublish
PubMed: 39450477 DOI: 10.1177/0271678X241295857
Anesthetics in pathological cerebrovascular conditions.
J Cereb Blood Flow Metab 45(1):32-47
Authors: Yuhui Hou, Wei Ye, Ziyuan Tang, Fengxian Li
Affiliations
- Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
- Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China. Key Laboratory of Mental Health of the Ministry of Education, Guangdong Province Key Laboratory of Psychiatric Disorders, Southern Medical University, Guangzhou, China.
Abstract
The increasing prevalence of pathological cerebrovascular conditions, including stroke, hypertensive encephalopathy, and chronic disorders, underscores the importance of anesthetic considerations for affected patients. Preserving cerebral oxygenation and blood flow during anesthesia is paramount to prevent neurological deterioration. Furthermore, protecting vulnerable neurons from damage is crucial for optimal outcomes. Recent research suggests that anesthetic agents may provide a potentially therapeutic approach for managing pathological cerebrovascular conditions. Anesthetics target neural mechanisms underlying cerebrovascular dysfunction, thereby modulating neuroinflammation, protecting neurons against ischemic injury, and improving cerebral hemodynamics. However, optimal strategies regarding mechanisms, dosage, and indications remain uncertain. This review aims to clarify the physiological effects, mechanisms of action, and reported neuroprotective benefits of anesthetics in patients with various pathological cerebrovascular conditions. Investigating anesthetic effects in cerebrovascular disease holds promise for developing novel therapeutic strategies.
MeSH
Neurons, Neuroprotection, Anesthetics, Cerebrovascular Circulation, Neurovascular Coupling, Therapeutics