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Journal Article Review Epublish 46 citations

PubMed: 39452955 DOI: 10.3390/nano14201618

Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications.

Nanomaterials (Basel) 14(20)

Authors: Furkan Eker, Hatice Duman, Emir Akdaşçi, Anna Maria Witkowska, Mikhael Bechelany, Sercan Karav

Affiliations

  • Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Türkiye.
  • Department of Food Biotechnology, Medical University of Bialystok, 15-089 Bialystok, Poland.
  • Institut Européen des Membranes (IEM), UMR 5635, University Montpellier, ENSCM, CNRS, F-34095 Montpellier, France.
  • Functional Materials Group, Gulf University for Science and Technology (GUST), Masjid Al Aqsa Street, Mubarak Al-Abdullah 32093, Kuwait.

Abstract

Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The unique characteristics of silver NPs, such as their higher surface-area-to-volume ratio, make them ideal for a variety of biological applications. They are easily processed thanks to their large surface area, strong surface plasmon resonance (SPR), stable nature, and multifunctionality. With an emphasis on the mechanisms of action, efficacy, and prospective advantages of silver NPs, this review attempts to give a thorough overview of the numerous biological applications of these particles. The utilization of silver NPs in diagnostics, such as bioimaging and biosensing, as well as their functions in therapeutic interventions such as antimicrobial therapies, cancer therapy, diabetes treatment, bone repair, and wound healing, are investigated. The underlying processes by which silver NPs exercise their effects, such as oxidative stress induction, apoptosis, and microbial cell membrane rupture, are explored. Furthermore, toxicological concerns and regulatory issues are discussed, as well as the present difficulties and restrictions related to the application of silver NPs in medicine.

MeSH

Diabetes Mellitus, Nanoparticles, Therapeutics

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