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Journal Article Review Epublish 1 citation

PubMed: 39456822 DOI: 10.3390/ijms252011040

Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, L., in Long COVID and Other Conditions Involving Cognitive Impairment.

Int J Mol Sci 25(20)

Authors: Paraskevi Papadopoulou, Alexia Polissidis, Georgia Kythreoti, Marina Sagnou, Athena Stefanatou, Theoharis C Theoharides

Affiliations

  • Department of Science and Mathematics, Deree-The American College of Greece, 15342 Athens, Greece.
  • Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, 15310 Athens, Greece.
  • School of Graduate & Professional Education, Deree-The American College of Greece, 15342 Athens, Greece.
  • Institute for Neuro-Immune Medicine-Clearwater, Clearwater, FL 33759, USA.
  • Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.

Abstract

The European olive tree, L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. This review examines the evidence for the anti-inflammatory and neuroprotective actions of olive polyphenols and their potential in the treatment of long COVID and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Key findings suggest that olive polyphenols exhibit antioxidant, anti-inflammatory, neuroprotective, and antiviral properties, making them promising candidates for therapeutic intervention, especially when formulated in unique combinations. Recommendations for future research directions include elucidating molecular pathways through mechanistic studies, exploring the therapeutic implications of olive polyphenol supplementation, and conducting clinical trials to assess efficacy and safety. Investigating potential synergistic effects with other agents addressing different targets is suggested for further exploration. The evidence reviewed strengthens the translational value of olive polyphenols in conditions involving cognitive dysfunction and emphasizes the novelty of new formulations.

MeSH

Blood-Brain Barrier, Cognitive Dysfunction, Oxidative Stress, Olive Oil, Cognition Disorders, Therapeutics, Neurodegenerative Diseases, Polyphenols, Post-Acute Covid-19 Syndrome

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