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Journal Article Review Epublish 10 citations

PubMed: 39460347 DOI: 10.3390/vaccines12101181

T-Cell Epitope-Based Vaccines: A Promising Strategy for Prevention of Infectious Diseases.

Vaccines (Basel) 12(10)

Authors: Xin Song, Yongfeng Li, Hongxia Wu, Huaji Qiu, Yuan Sun

Affiliations

  • State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

Abstract

With the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines. T-cell epitope-based vaccines leverage specific immunogenic peptides to elicit protective T-cell responses against infectious pathogens. Compared to traditional vaccines, they provide superior efficacy and safety, minimizing the risk of adverse side effects. In this review, we summarized and compared the prediction and identification methods of T-cell epitopes. By integrating bioinformatic prediction and experimental validation, efficient and precise screening of T-cell epitopes can be achieved. Importantly, we delved into the development approaches to diverse T-cell epitope-based vaccines, comparing their merits and demerits, as well as discussing the prevalent challenges and perspectives in their applications. This review offers fresh perspectives for the formulation of safe and efficacious epitope-based vaccines for the devastating diseases against which no vaccines are currently available.

MeSH

Cells, Epitopes, Vaccines, T-Lymphocytes, Communicable Diseases, Epitopes, T-Lymphocyte

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