System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Epublish 2 citations

PubMed: 39494333 DOI: 10.7150/ijbs.98107

Harnessing the Anti-Inflammatory Properties of Polyphenols in the Treatment of Inflammatory Bowel Disease.

Int J Biol Sci 20(14):5608-5672

Authors: Diego Liviu Boaru, Oscar Fraile-Martinez, Diego De Leon-Oliva, Cielo Garcia-Montero, Patricia De Castro-Martinez, Alejandro Miranda-Gonzalez, Miguel A Saez, Leticia Muñon-Zamarron, Elisa Castillo-Ruiz, Silvestra Barrena-Blázquez, Rafael Cañonez-Zafra, Miguel Ángel Alvarez-Mon, Maria V Toledo-Lobo, Ana M Minaya-Bravo, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Jose V Saz, Agustin Albillos, Melchor Alvarez-Mon, Luis G Guijarro, Miguel A Ortega

Affiliations

  • Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, Alcalá de Henares, Spain.
  • Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
  • Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Spain.
  • Department of Biomedicine and Biotechnology, University of Alcalá, 28801 Alcalá de Henares, Spain.
  • Department of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias University Hospital, Alcalá de Henares, Spain.
  • Gastroenterology and Hepatology Departament. Ramón y Cajal University Hospital, Madrid, Spain; Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain; Network Research Center for Liver and Digestive Diseases (CIBEREHD), Madrid, Spain; University of Alcalá, Madrid, Spain.
  • Immune System Diseases-Rheumatology, Oncology Departament and Internal Medicine (CIBEREHD), Príncipe de Asturias University Hospital, Alcalá de Henares, Spain.
  • Unit of Biochemistry and Molecular Biology, Department of System Biology (CIBEREHD), University of Alcalá, Alcalá de Henares, Spain.

Abstract

Inflammatory bowel disease (IBD) encompasses a spectrum of chronic inflammatory conditions affecting the gastrointestinal tract, notably ulcerative colitis (UC) and Crohn's disease (CD). Both UC and CD result from the interplay between genetic and environmental factors that trigger an exacerbated immune response against gut microorganisms, leading to non-resolving inflammatory damage in the mucosa of specific zones in the intestine. Despite extensive research, current treatments often entail invasive interventions with considerable adverse effects on patient well-being. Consequently, there is a pressing need to find alternative and complementary therapeutic strategies aimed at ameliorating chronic inflammation and restoring intestinal barrier integrity. Polyphenols are plant-based compounds formed naturally or as semi-synthetic/synthetic derivatives with proven health-promoting effects and translational applications in a broad spectrum of chronic diseases. Preclinical models of IBD largely support the efficacy of a broad variety of polyphenols due to their well-documented antioxidant and modulatory properties on the immune system and gut microbiota. Likewise, a growing number of studies using distinct types of polyphenols are being conducted in humans, although more efforts are still warranted. In the present review, the main polyphenols investigated and models of IBD will be summarized, as well as the available trials or observational data accessible in humans. Finally, the role of polyphenols in the clinical context of IBDs, along with the main problematics regarding their translational issues and concerns will be discussed, including bioavailability, their inclusion in healthy dietary patterns and foods, interaction with other drugs, and other important points to be addressed by future research.

MeSH

Biological Science Disciplines, Antioxidants, Inflammatory Bowel Diseases, Research, Therapeutics, Gastrointestinal Microbiome, Colitis, Ulcerative, Polyphenols

Cited by