Journal Article Meta-Analysis Ppublish
PubMed: 39496035 DOI: 10.1097/MD.0000000000040141
Different intensities of physical activity for amyotrophic lateral sclerosis and Parkinson disease: A Mendelian randomization study and meta-analysis.
Medicine (Baltimore) 103(44):e40141
Authors: Wenyuan Xu, Xianghu Zhao, Jiaying Wang, Yujie Guo, Zhihao Ren, Lian Cai, Shengbing Wu, Meiqi Zhou
Affiliations
- Graduate School, Anhui University of Chinese Medicine, Hefei, China.
- College of Sports Medicine, Wuhan Sports University, Wuhan, China.
- Institute of Acupuncture-Moxibustion and Meridians, Anhui Academy of Traditional Chinese Medicine, Hefei, China.
- Anhui Province Key Laboratory of Meridian Viscera Correlationship, Hefei, China.
- Graduate School, Anhui University of Chinese Medicine, Hefei, China. Institute of Acupuncture-Moxibustion and Meridians, Anhui Academy of Traditional Chinese Medicine, Hefei, China. Anhui Province Key Laboratory of Meridian Viscera Correlationship, Hefei, China.
Abstract
BACKGROUND
The causal relationships between amyotrophic lateral sclerosis (ALS), Parkinson disease and different intensities of physical activity (PA) are still inconclusive. To evaluate the causal impact of PA on ALS and Parkinson disease (PD), this study integrates evidence from Mendelian randomization (MR) using a meta-analysis approach.
METHODS
MR analyses on genetically predicted levels of PA (compose of self-reported moderate-to-vigorous physical activity [MVPA], self-reported vigorous physical activity [VPA], and strenuous sports or other exercises [SSOE]) regarding ALS and PD published up to July 27, 2024, were obtained from PubMed, Scopus, Web of Science, and Embase. De novo MR studies were analyzed utilizing publicly accessible datasets from genome-wide association studies and then meta-analyses were performed to pool the results.
RESULTS
Meta-analyses of results of 12 de novo MR studies analyses and 2 published MR studies indicated that genetic predicted levels of MVPA (odds ratio [OR]: 1.22, 95% confidence interval [CI]: 1.08-1.38), VPA (OR: 1.32, 95% CI: 1.08-1.60), and SSOE (OR: 1.35, 95% CI: 1.07-1.70) were related to a raised risk of ALS, but not causally with PD.
CONCLUSION
Our findings showed no causal relationships between MVPA, VPA, SSOE, and PD, while MVPA, VPA, and SSOE were associated with increased ALS risk, highlighting the need for targeted PA recommendations for disease management.
MeSH
Exercise, Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Random Allocation