Journal Article Research Support, Non-U.S. Gov't Epublish
PubMed: 39513920 DOI: 10.3390/cells13211813
The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells.
Cells 13(21)
Authors: Snezhanna Kandrashina, Ekaterina Sherstyukova, Mikhail Shvedov, Vladimir Inozemtsev, Roman Timoshenko, Alexander Erofeev, Maxim Dokukin, Viktoria Sergunova
Affiliations
- Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.
- Research laboratory of biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.
- Sarov Physics and Technology Institute, MEPhI, 607186 Sarov, Russia.
Abstract
Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell's elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.
MeSH
Cells, Erythrocytes, Blood, Cytoskeleton, Nanostructures, Blood Cells, Acid-Base Imbalance, Plasma