Journal Article Epublish
PubMed: 39518406 DOI: 10.3390/diagnostics14212439
Sentinel Lymph Node Biopsy in Breast Cancer Using Different Types of Tracers According to Molecular Subtypes and Breast Density-A Randomized Clinical Study.
Diagnostics (Basel) 14(21)
Authors: Ionut Flaviu Faur, Amadeus Dobrescu, Ioana Adelina Clim, Paul Pasca, Catalin Prodan-Barbulescu, Cristi Tarta, Carmen Neamtu, Alexandru Isaic, Dan Brebu, Vlad Braicu, Catalin Vladut Ionut Feier, Ciprian Duta, Bogdan Totolici
Affiliations
- IInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
- X Department of General Surgery, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
- Multidisciplinary Doctoral School "Vasile GoldiÈ™", Western University of Arad, 310025 Arad, Romania.
- IInd Obstetrics and Gynecology Clinic "Dominic Stanca", 400124 Cluj-Napoca, Romania.
- Department I, Discipline of Anatomy and Embriology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
- Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
- Faculty of Dentistry, "Vasile GoldiÈ™" Western University of Arad, 310025 Arad, Romania.
- Ist Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania.
- First Surgery Clinic, "Pius Brinzeu" Clinical Emergency Hospital, 300723 Timisoara, Romania.
- Department of General Surgery, Faculty of Medicine, "Vasile GoldiÈ™" Western University of Arad, 310025 Arad, Romania.
Abstract
Sentinel lymph node biopsy (SLNB) has become a method more and more frequently used in loco-regional breast cancer in the initial stages. Starting from the first report on the technical feasibility of the sentinel node method in breast cancer, published by Krag (1993) and Giuliano (1994), the method underwent numerous improvements and was also largely used worldwide. This article is a prospective study that took place at the "SJUPBT Surgery Clinic Timisoara" over a period of 1 year between July 2023 and July 2024, during which 137 underwent sentinel lymph node biopsy (SLNB) based on the current guidelines. For the identification of sentinel lymph nodes, we used various methods, including single traces and also a dual tracer and triple tracer. Breast density represents a predictive biomarker for the identification rate of a sentinel node, being directly correlated with BMI (above 30 kg/m) and with an age of above 50 years. The classification of the patients according to breast density represents an important criterion given that an adipose breast density (Tabar-Gram I-II) represents a lower IR of SLN compared with a density of the fibro-nodular type (Tabar-Gram III-V). We did not obtain any statistically significant data for the linear correlations between IR and the molecular profile, whether referring to the luminal subtypes (Luminal A and Luminal B) or to the non-luminal ones (HER2+ and TNBC), with > 0.05, 0.201 [0.88, 0.167]; z = 1.82.
MeSH
Lymph Nodes, Breast Neoplasms, Methylene Blue, Neoplasms, Sentinel Lymph Node, Biopsy, Lymph, Breast, Breast Density, Sentinel Lymph Node Biopsy